Search results for " KRAS"
showing 10 items of 26 documents
Variability of growth pattern observed in Metoposaurus krasiejowensis humeri and its biological meaning
2017
Purpose Histological studies on temnospondyl amphibian bones remain rare. A systematic revision of the histology was applied for the purpose of testing the histovariability in the humeri and becoming new information about the growth pattern. Methods The present study includes 12 humeri of Metoposaurus krasiejowensis, which originate from the Late Triassic clay pit near Krasiejo´w, southwestern Poland. The specimens were scanned with a microCT and the histological thin-sections have been obtained with the standard petrographic method. Results The evaluation of the studied bones shows a uniform growth series resulting in one morphotype. Strikingly, the histological analysis reveals a greater …
Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC
2017
[EN] Background Reported prevalence of driver gene mutations in non-small-cell lung cancer (NSCLC) is highly variable and clinical correlations are emerging. Using NSCLC biomaterial and clinical data from the European Thoracic Oncology Platform Lungscape iBiobank, we explore the epidemiology of mutations and association to clinicopathologic features and patient outcome (relapse-free survival, time-to-relapse, overall survival). Methods Clinically annotated, resected stage I¿III NSCLC FFPE tissue was assessed for gene mutation using a microfluidics-based multiplex PCR platform. Mutant-allele detection sensitivity is¿>1% for most of the ~150 (13 genes) mutations covered in the multiplex test.…
Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis.
2016
Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of CRC-related liver metastases (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients undergoing resection of CLM, stratified according to KRAS and/or BRAF mutation status. Background: Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of CRC-related liver metast…
Pulmonary Adenocarcinoma With Enteric Differentiation: Immunohistochemistry and Molecular Morphology
2018
Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently recognized in the WHO classification. It is defined as an adenocarcinoma in which the enteric component exceeds 50% and have to show the expression of at least 1 immunohistochemical marker of enteric differentiation. Although the definition of this tumor type is very important, above all in the differential diagnosis between a primary lung tumor and a metastasis of colorectal adenocarcinoma, this cancer still lacks a distinctive immunohistochemical and molecular signature. We recruited the largest series in the literature of PAEDs according to the morphology and the positivity for …
La CGT : passé, présent. Comptes rendus croisés de L. Cancouët, Mémoires d’un authentique prolétaire (Vendémiaire, 2011), L. de Comarmond, Les vingt …
2014
International audience
Sikspārņu rudens migrācijas intensitāte atkarībā no attāluma līdz jūras krastam un no meteoroloģiskajiem apstākļiem
2019
Sikspārņu rudens migrācijas laikā vēja parkos ir novērota liela sikspārņu mirstība. Šīs migrācijas laikā liels skaits sikspārņu migrē gar jūras krastu. Lai pēc iespējas sikspārņu mirstību samazinātu, ir nepieciešams noteikt augsta riska zonas, kurās vēja parkus būvēt nedrīkst, kā arī ir svarīgi spēt paredzēt sikspārņu migrācijas intensitāti pēc meteoroloģiskajiem faktoriem. LU Bioloģijas institūta ornitoloģisko pētījumu stacijā Papē no 11. līdz 25. augustam ar automātiskiem ultraskaņas detektoriem tika ierakstīts sikspārņu nakts pārlidojumu skaits piecos dažādos attālumos no jūras krasta. 74,6 % no visiem pārlidojumiem tika novēroti trīs aktīvākajās migrācijas naktīs, un 46,3 % no visiem pā…
Fixed point iterative schemes for variational inequality problems
2018
In a wide class of evolutionary processes, the problem of computing the solutions of an initial value problem is encountered. Here, we consider projected dynamical systems in the sense of \cite{Daniele} and references therein. Precisely, a projected dynamical system is an operator which solves the initial value problem: \begin{equation}\label{PDS}\frac{dx(t)}{dt}= \Pi_{\mathbb{K}}\left(x(t),-F(x(t))\right), \quad x(0)=x_0 \in \mathbb{K}, \, t \in [0,+\infty[,\tag{P}\end{equation} where $\mathbb{K}$ is a convex polyhedral set in $\mathbb{R}^n$, $F: \mathbb{K} \to \mathbb{R}^n$ and $\Pi_{\mathbb{K}}: \mathbb{R} \times \mathbb{K} \to \mathbb{R}^n$ is given as follows $\Pi_{\mathbb{K}}(x,-F(x))…
Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells
2015
Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon will be the second leading cause of cancer death in the USA. This is a deadly malignancy with an incidence that approximates the mortality with 44,000 new cases and 36,000 deaths each year. Surgery, although only modestly successful, is the only curative option. However, due the locally aggressive nature and early metastasis, surgery can be performed on less than 20% of patients. Cytotoxic chemotherapy is palliative, has significant toxicity and improves survival very little. Thus new treatment paradigms are needed desperately. Due to the extremely high frequency of KRAS gene mutations (>90%) d…
Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: results of the EXPERT-C trial
2015
KRAS mutation has been reported as a marker of radio-resistance in rectal cancer and unfavourable outcome in both colon and rectal cancer. This study suggests that a single-nucleotide polymorphism of the KRAS gene (LCS-6 variant) may predict response to neoadjuvant treatment and mitigate the poor prognosis associated with KRAS mutation in locally advanced rectal cancer.
Hitler regala una città agli ebrei. Musica e cultura nel ghetto di Theresienstadt
2008
l volume ricostruisce la vicenda culturale del ghetto di Theresienstadt, nel quadro della "soluzione finale" del problema ebraico (1941-45). In particolare, vengono descritte le biografie e le più importanti partiture realizzate - prima e durante la loro deportazione - da alcuni fra i compositori rinchiusi nel Lager (Pavel Haas, Hans Krasa, Viktor Ullmann). Il testo si avvale di un repertorio iconografico proveniente, in parte, dagli archivi del Unites States Holocaust Memorial Museum di Washington D.C. e del Yad Vashem di Gerusalemme. In appendice è riportata la prima traduzionelie italiana del saggio di Miroslav Karny "Il Lager per famiglie di Theresienstadt (BIIb) a Birkenau (settembre 1…